Implications of hcv natural genetic diversity on HCV NS5B inhibitor NM283
نویسندگان
چکیده
منابع مشابه
Effect of hepatitis C virus (HCV) NS5B-nucleolin interaction on HCV replication with HCV subgenomic replicon.
We previously reported that nucleolin, a representative nucleolar marker, interacts with nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) through two independent regions of NS5B, amino acids 208 to 214 and 500 to 506. We also showed that truncated nucleolin that harbors the NS5B-binding region inhibited the RNA-dependent RNA polymerase activity of NS5B in vitro, suggesting that nucleo...
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ژورنال
عنوان ژورنال: Retrovirology
سال: 2010
ISSN: 1742-4690
DOI: 10.1186/1742-4690-7-s1-p28